Miyo KANOU
Safety evaluation of pesticides in drinking water sources by mutagen formation potential
Toshiya KOMATSU, Shuji HIMENO
One hundred and one pesticides are listed as ¡ÈComplementary Items for setting the Targets for Water Quality Management in Japan¡É. The purposes of this study were to select important pesticides from the lists in drinking water sources, and to evaluate the selected pesticides from a viewpoint of genotoxicity.
Seven pesticides (dichlorvos, molinate, mefenacet, fenitrothion, isoprothiolane, bromobutide and pyroquilon) were selected by the investigation of papers and measurement of pesticides in river waters. Mutagenicity of the pesticides, the mutagen formation potential (MFP) on chlorination, and the MFP of the biodegradation products were measured. Ames mutagenicity assays were conducted using S.tyhimurium strain TA100 without metabolic activation
As the results, dichlorvos was not a mutagen precursor. However, the pesticide itself showed high mutagenicity. In the case of fenitrothion and pyroquilon, both MFP and MFP of the biodegradation products showed high values. Especially, the highest values were observed in fenitrothion. On the other hand, other four pesticides were considered to have a low genotoxicity risk in water environment.
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